Top Mississippi River Cruises Offered by American Cruise Lines (UPDATED 2026)

By Jackie Sheckler Finch

Updated March 2026

Cruising the mighty Mississippi and its tributaries has been my pleasure since 1976. Someone asked me once if it doesn’t get tiresome watching the river day after day.

For me, definitely not.

As America’s first highway, the Mississippi River is one of the longest rivers in the world, starting as a trickle out of Lake Itasca in northern Minnesota and flowing 2,348 miles to surge into the Gulf of Mexico.

As the Mississippi River flows from north to south, it is joined by other rivers known as tributaries, which add to its volume and strength.

There’s only one cruise line — American Cruise Line — that operates numerous itineraries on the Mississippi and its picturesque tributaries, including the Tennessee, Ohio and Cumberland rivers.

Top Mississippi River Cruises, Including Tributaries

I’ve been asked many times what cruises on the Mississippi River and its tributaries I recommend.

Since 1976, when I went on the inaugural cruise of the Mississippi Queen, I’ve enjoyed more than 75 cruises on the Mississippi River and its tributaries (with a few more planned for this year and next).

So I do know the many charms of the these glorious river cruises.

I’ve cruised on many modern riverboats, traditional paddle steamers and even two barges that were joined together to make a river cruiser.

Like the magnificent Mississippi Queen, many of those boats and ships are now gone. But I’m still cruising and discovering new adventures with every trip on the Mississippi and its tributaries.

I must admit I’ve never met a ship or a river I didn’t like but some do seem to have more charms than others.

So much to see and do on river cruises. Big cities and small towns along the river welcome passengers and share what makes their places special.

When describing the 2026 and 2027 Mississippi River cruises offered by American Cruise Lines below, I’ve included tips about some of my favorite shore excursions on each itinerary and I also share my main reason for choosing each itinerary.

Keep in mind that the itineraries also go in the reverse. In other words, if a cruise goes from Memphis to New Orleans, it also goes from New Orleans to Memphis. Up to you, which embarkation port you choose because you get to spend a pre-cruise night in that city; that’s part of American Cruise Lines’ all-inclusive package. Also note, when cruises start and end in different ports (as many Mississippi River cruises do), be sure to factor that into your transport — if you're flying, you may have to fly into one airport and out of another, or take a taxi or rental car back to the first airport. Same if you're driving; you'll have to get back to your car if the cruise ends in a different place from where it started.

The American Cruise Lines Ships

What also keeps cruising the Mississippi and her tributaries interesting is the new ships that come along and the innovative itineraries that American Cruise Lines comes up with year after year.

Currently, American Cruise Lines has five ships that cruise the Mississippi River and its tributaries on 17 different itineraries:

Two Classic Paddlewheelers

Note, these ships' large rear stern-wheels are authentic, turning in the water to help move the vessels while also providing a nostalgic atmosphere; the vessels are powered by modern diesel engines (not steam!) that drive the paddlewheel along with Z-drive azimuth thrusters for maneuverability and speed.

• American Heritage (150 pax, built 2015)
• American Splendor (180 pax, built 2016)

Three Modern River Boats

Note, each has an unusual forward bow that opens up (like photo below) for easy access walking to shore when not pulled along side a traditional dock.

• American Melody (180 pax, built 2021)
• American Symphony (180 pax, built 2022)
• American Serenade (180 pax, built 2023)

For each of the American Cruise Lines itineraries I’m highlighting below, I’m calling out one of my favorite shore excursions.

Keep in mind, each cruise stop has multiple shore excursion options; in some cases, it’ll be difficult to decide which to take. I know, I always want to do them all. Some people use shore excursions to help decide what cruise to take; that's up to you.

So here we go, below I describe American Cruise Lines' 17 top cruises on the Mississippi River and its tributaries.

1. Tennessee River Cruise (7 Nights)

The Tennessee River is 652 miles long and flows through the states of Tennessee, Alabama, Mississippi and Kentucky. In the 1903s, the Tennessee Valley Authority (TVA) brought electricity and flood control which helped spur economic growth. The TVA’s system of dams, reservoirs and locks transformed the rivers with engineering marvels into the vital waterways of today.

On this cruise, a highlight of the journey is going through Wilson Lock and Dam, one of the tallest locks in the United States. With an elevation change of about 93 feet, passing through the lock showcases the power of harnessing the forces of nature.

An additional treat is a day cruising through Lake Barkley and the Cumberland River with beautiful views of rolling hills, open fields, old growth timber and picturesque bluffs.

Cruisers can admire the scenic beauty of places like Land Between the Lakes, a wooded peninsula nestled between the Tennessee River’s Kentucky Lake and the Cumberland River’s Lake Barkley.

Tennessee River Cruise Itinerary

8 Nights Total: 7-night cruise plus 1 pre-cruise hotel night

Start/End Points:

• Chattanooga, Tennessee
• Nashville, Tennessee

Ports:

• Chattanooga, Tennessee
• Decatur, Alabama
• Florence, Alabama
• Savannah, Tennessee
• Paducah, Kentucky
• Nashville, Tennessee

ACL ships that cruise this itinerary:

• American Symphony
• American Splendor

Why Choose This Mississippi Cruise?

No matter the time of day or night, excited passengers always head out to the deck when the ship goes through a lock and dam. Fascinating to see, even if you’ve seen it before.

My Shore Excursion Pick: Helen Keller Home at Florence, Alabama

The toddler began walking and talking at an early age. Then, when she was 19 months old, the child became very sick, diagnosed with brain fever, perhaps scarlet fever. The illness left her deaf and blind.

For the rest of the story, take a shore excursion to Tuscumbia, Alabama, to a white frame cottage called Ivy Green. The child, of course, was Helen Keller. Born on March 3, 1887, young Helen became wild and uncontrollable as she was unable to communicate. She was lost in utter silence and darkness until the arrival of her 20-year-old teacher, Anne Sullivan,

One day, Helen went to the outdoor pump where Anne began pumping water. Putting the child’s hand under the spout, Anne repeatedly spelled into the other hand the word “w-a-t-e-r.”

“I stood still,” Helen later wrote,” my whole body’s attention fixed on the motions of her fingers as the cool stream flowed over my hand. All at once here was a strange stir within me — a misty consciousness, a sense of something remembered. It was as if I had come back to life after being dead!”

The house where Helen was born and died of a heart attack on June 1, 1968, at 87 years old is preserved much as it was when Helen lived there. The iconic water pump remains as a beloved symbol of when seven-year-old Helen, as she said, came “back to life.”

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2. Ohio River Cruise (7 Nights)

At 981 miles long, the Ohio River begins in Pittsburgh and flows to Cairo, Illinois, where it empties into the Mississippi River. The Ohio River flows through or borders six states — Illinois, Indiana, Kentucky, Ohio, Pennsylvania and West Virginia.

America’s founding father Thomas Jefferson once said that “The Ohio is the most beautiful river on earth. Its current gentle, waters clear and bosom smooth and unbroken by rocks and rapids, a single instance only excepted.”

Ohio River Cruise Itinerary

8 Nights Total: 7-night cruise plus 1 pre-cruise hotel night

Start/End Points:

• Louisville, Kentucky
• Pittsburgh, Pennsylvania

Ports:

• Louisville, Kentucky
• Madison, Indiana
• Cincinnati, Ohio
• Marietta, Ohio
• Pittsburgh, Pennsylvania

ACL ships that cruise this itinerary:

• American Symphony
• American Melody
• American Heritage

Why Choose This Mississippi Cruise?

The big cities on this cruise offer so much to see and do. But little Madison, Indiana, also has a claim to fame. With a population of just over 12,000, Madison has the largest contiguous National Historic Landmark District in the nation.

Shore Excursion Tip: Great American Ball Park in Cincinnati

Hearing the number of runs that Pete Rose hit during his baseball career is impressive. Seeing them is mind boggling. A 50-foot-tall “wall of balls” at the Cincinnati Reds Hall of Fame and Museum brings home that staggering fact. Arranged in rows, the three-story wall has 4,256 baseballs for the record set by Rose in 3,562 games over 24 seasons.

The place is not only for Reds’ fans. It is for anyone who loves baseball. It’s easy to find the museum. A large statue of Rose sliding into base honors “Charlie Hustle” in front of the stadium located on Pete Rose Way.

Rose was an integral part of the famed “Big Red Machine,” the Reds team that from 1970 to 1976 won five division titles, four NL pennants and two World Series championships. Learn so much more at this fascinating museum and ballpark.

3. Highlights Of The Mississippi Cruise (7 Nights)

Often called the Highlights of the Mississippi Cruise, the name sure makes me want to do this one. And in fact, I have done it several times on several different ships.

After all, the mighty Mississippi River was America’s first highway. Appropriately, this cruise goes roundtrip from New Orleans, once one of the busiest ports in the world. In fact, the first steamboat — named the New Orleans — arrived in New Orleans on Jan. 12, 1812.

If you can, plan to stay a few extra days before or after your cruise in the Big Easy. Listen to the jazz, eat some jambalaya, stroll through the French Quarter, admire the Garden District and pay homage at the National World War II Museum. Never a lack of exciting things to see and do in “The City That Care Forgot.”

Highlights Of The Mississippi Cruise

8 Nights Total: 7-night cruise plus 1 pre-cruise hotel night

Start/End Point:

• New Orleans

Ports:

• New Orleans, Louisiana
• Oak Alley/Houmas House, Louisiana
• Baton Rouge, Louisiana
• Natchez/Vicksburg, Mississippi
• St. Francisville, Louisiana
• New Orleans, Louisiana

ACL ships that cruise this itinerary:

• American Symphony
• American Melody
• American Serenade
• American Heritage

Why Choose This Mississippi Cruise?

This cruise features many Louisiana ports which makes it so delightful. Shore excursions are excellent so it can be difficult to decide which ones to do. Easy solution would be to take this cruise again someday. Another plus in terms of transport between your home and the ship, is this cruise sails round-trip from the same port (New Orleans)

Shore Excursion Tip — Haunted Myrtles

Built in 1796 and surrounded by centuries-old live oaks, Myrtles seems like such a peaceful place. However, it is reputed to be one of the most haunted homes in America. Take a tour during a stop in St. Francisville, Louisiana, and decide for yourself.

One of the ghostly apparitions is said to be a former house slave named Chloe who was caught eavesdropping on the owner, a prestigious judge. As punishment, the judge had one of Chloe’s ears cut off. To hide her shame, Chloe wore a green turban.

As a result, Chloe made a cake with a lethal dose of poisonous oleander leaves which killed the judge’s wife and two of his children. Other slaves took revenge by hanging Chloe and throwing her body into the Mississippi river.

Since then, photographs have reportedly captured Chloe’s ghost around the house and fingerprints on a mirror reappear whenever they are cleaned off. When I was touring the house, we were listening to a tour guide explain the mysterious sightings when suddenly an antique cabinet door opened.

No one could explain why but the guide quickly exited the room. And we quickly followed.

4. Lower Mississippi River Cruise (7 Nights)

The Mississippi River is usually referred to in two parts — the Upper Mississippi and the Lower Mississippi. The Lower Mississippi flows from St. Louis downriver to New Orleans and the gulf.

Picking up sediment as it goes, the Mississippi becomes a powerful muddy-colored river as it heads south. The river reaches its deepest point near Algiers Point in New Orleans, measuring 200 feet deep — a far cry from its 18-inch depth near its headquarters in Minnesota.

Upper and Lower cruise itineraries for American Cruise Lines are so noted and are quite different. Each river section has its own characteristics making it well worthwhile to cruise both or, if possible, to enjoy a cruise of the whole Mississippi River.

Lower Mississippi River Cruise Itinerary

8 Nights Total: 7-night cruise plus 1 pre-cruise hotel night

Start/End Points:

• Memphis, Tennessee
• New Orleans, Louisiana

Ports:

• Memphis, Tennessee
• Cleveland, Mississippi
• Vicksburg, Mississippi
• Natchez, Mississippi
• Oak Alley/Houmas House, Louisiana
• New Orleans, Louisiana

ACL ships that cruise this itinerary:

• American Symphony
• American Melody
• American Serenade
• American Splendor
• American Heritage

Why Choose This Mississippi Cruise?

Any cruise starting in Memphis is going to be a favorite of mine. The optional Graceland Pre-Cruise Package is terrific. I’m always surprised when I hear passengers say they didn’t know such a treat was available. All passengers get that one pre-cruise night at The Guest House at Graceland. But the extra-night package at $575 per passenger is an excellent bargain. Check it out on the American Cruise Lines website or ask your travel agent. I’ve seen full-grown women get upset when they realize what they missed.

Shore Excursion Tip: Houmas House, Louisiana

The circa-1840 Greek Revival mansion is located between Baton Rouge and New Orleans on Louisiana’s historic River Road. Houmas House, the famous 16-room “Sugar Palace,” showcases the immense wealth this sugarcane farm boasted during the 1800s.

If the house looks familiar, it was the filming site for the famous 1964 Bette Davis/Joan Crawford movie, “Hush, Hush, Sweet Charlotte.” Make that the Bette Davis movie.

“Joan and Bette got into a fight,” Houmas House guide Danielle says. “Joan packed her bags and went back to Hollywood. They got Olivia de Havilland to replace Joan and had to reshoot all Joan’s scenes.”

A Houmas House bedroom is where Bette stayed. Her hat and purse are placed on the bed as though she has just stepped out for a cocktail and plans to return.

RELATED: A review of a Lower Mississippi River cruise aboard the American Melody.

5. Upper Mississippi River Cruise (7 Nights)

The Upper Mississippi River is the portion of the river upstream from St. Louis to Minneapolis and St. Paul. The weather is generally cooler in the Upper Mississippi than in the Lower Mississippi making it more pleasant during the summer.

In the Upper Mississippi, river bluffs and surrounding forests offer natural beauty and are home to many species of birds, fish and land mammals. Enjoy watching the ship navigate through a labyrinth of islands and get up close to the ingenious engineering of dams and locks.

Upper Mississippi River Cruise Itinerary

8 Nights Total: 7-night cruise plus 1 pre-cruise hotel night

Start/End Points:

• St. Louis, Missouri
• St. Paul, Minnesota

Ports:

• St. Louis, Missouri
• Hannibal, Missouri
• Muscatine, Iowa
• Dubuque, Iowa
• Winona, Minnesota
• Red Wing, Minnesota
• St. Paul, Minnesota

ACL ships that cruise this itinerary:

• American Symphony
• American Melody
• American Serenade
• American Heritage

Why Choose This Mississippi Cruise?

Because this cruise goes to Hannibal, Missouri, childhood hometown of Mark Twain. Take a copy of Twain’s book Life on the Mississippi to enjoy on the ship as you watch Twain’s beloved Mississippi River flowing by.

Shore Excursion Tip: Mark Twain Boyhood Home & Museum in Hannibal, Missouri

Visit the actual home that Samuel Clemens (Mark Twain) grew up in, which is surrounded by the legendary whitewashed fence of Tom Sawyer. Also see the Becky Thatcher House, Huck Finn Home and Tom and Huck statue at the top of Cardiff Hill.

6. Music Cities Cruise (7 Nights on 3 Rivers)

This cruise certainly lives up to its name. Starting in Memphis — known as the birthplace of both the blues and rock ‘n’ roll — and ending in Nashville — known as music city and the country music capital of the world — this cruise is perfect for a music fan.

River lovers will be happy to journey on three majestic rivers plus a lake on this journey — the mighty Mississippi River, the beautiful Ohio River, the tranquil Cumberland River and the scenic Lake Barkley.

The last night of the cruise includes a complimentary visit to the Grand Ole Opry to hear new country artists as well as longtime favorites.

Music Cities Cruise Itinerary

8 Nights Total: 7-night cruise plus 1 pre-cruise hotel night

Start/End Points:

• Memphis, Tennessee
• Nashville, Tennessee

Ports:

• Memphis, Tennessee
• Paducah, Kentucky
• Dover, Tennessee
• Clarksville, Tennessee
• Nashville, Tennessee

ACL ships that cruise this itinerary:

• American Symphony
• American Splendor

Why Choose This Mississippi Cruise?

From Memphis to Nashville, this is a music-lovers’ dream cruise. In Nashville, the ship docks at the end of Honky Tonk Highway, the nickname for Lower Broadway, so it is easy to walk to the many museums and bars with live music.

Shore Excursion Tip: Graceland in Memphis, Tennessee

American Cruise Lines offers a terrific pre-cruise in Memphis. All passengers get that one extra night at The Guest House at Graceland. But you can pay for an extra night plus much more. My grandson and I paid $575 each for the Graceland Pre-Cruise Package.

The package includes that extra night at The Guest House plus two Guest House breakfast vouchers, welcome reception with cocktails and hors oeuvres and an after-hours shuttle ride to Graceland to see and touch (wearing white cotton gloves) rare Elvis memorabilia usually kept away from the public eye.

The next day features a visit to Graceland plus a lunch voucher at Graceland. Remember that at age 22, Elvis bought Graceland in 1957 for $102,000 in cash after topping his record-breaking music success with the film “Love Me Tender.”

At the last Graceland tour stop, visitors walk though Meditation Garden where Elvis is buried along with his parents, his 54-year-old daughter Lisa Marie, who died of cardiac arrest on Jan. 12, 2023, and his 27-year-old grandson Benjamin Keough, who committed suicide on July 12, 2020.

7. Mississippi Explorer Cruise (11 Nights)

New in 2025, the Mississippi Explorer Cruise stops at some of the best ports on the Mississippi River. Passengers can leisurely explore what makes these places special. The captivating journey cruises past verdant shores, cottonwood trees, bustling cities and small towns. Catch a glimpse of graceful blue herons, soaring bald eagles and shy white pelicans.

Mississippi Explorer Cruise Itinerary

12 Nights Total: 11-night cruise plus 1 pre-cruise hotel night)

Start/End Points:

• New Orleans, Louisiana
• Memphis, Tennessee

Ports:

• New Orleans, Louisiana
• Oak Alley/Houmas House, Louisiana
• St. Francisville, Louisiana
• Natchez, Mississippi
• Vicksburg, Mississippi
• Cleveland, Mississippi
• Tunica, Mississippi
• Memphis, Tennessee

ACL ships that cruise this itinerary:

• American Serenade
• American Melody
• American Heritage

Why Choose This Mississippi Cruise?

This cruise is like two cruises in one. It's twice as long as many of American's Mississippi cruises, sailing north along the entire length of the Mississippi River to share so many memorable stops along the way. 

Shore Excursion Tip: Cochon de Lait in St. Francisville, Louisville

The Cochon de lait is a double treat. This shore excursion features a traditional pig roast with all the delicious dishes that go with it, plus live Cajun music and dancing.

To make it even better, the event is held on Bayou Sara at a popular local restaurant, The Oyster Bar, which is closed to the public for our lunch.

Lunch was ready when we arrived including the pork, Louisiana boudin, potato salad, green beans, vegetable salad, bread, crackers and sauces, plus beer, wine and soft drinks. Pronounced “boo-dan,” boudin is a cooked sausage made from pork meat and rice, along with various vegetables and seasonings, all stuffed in a natural pork casing.

8. Smoky Mountains National Park Land & Cruise Combo (10 Nights)

Now, this is a wonderful way to visit one of the nation’s treasures – Great Smoky Mountains National Park. America’s most visited national park stretches across the border between North Carolina and Tennessee.

The mountain peaks are shrouded in a misty veil that looks like smoke and gives the range its name. The land tour with stays at hotels meets the ship on itinerary Day 5 in Chattanooga.

In Cades Cove, passengers travel in a caravan of Jeeps with narrators who share the history of the Great Smoky Mountains.

Smoky Mountains National Park Land & Cruise Combo Itinerary

10 Nights Total: land and cruise combo

Start/End Points:

• Knoxville, Tennessee
• Nashville, Tennessee

Ports:

• Knoxville, Tennessee
• Pigeon Forge, Tennessee
• Great Smoky Mountains National Park
• Chattanooga, Tennessee
• Decatur, Alabama
• Florence, Alabama
• Savannah, Tennessee
• Paducah, Tennessee
• Nashville, Tennessee

Ships that cruise this itinerary:

• American Symphony
• American Splendor

Why Choose This Mississippi Cruise?

This is the perfect way to see the Great Smoky Mountains National Park. Stay half the itinerary at hotels for the land tour. The other half is a relaxing river cruise.

Shore Excursion Tip — Clingmans Dome in Great Smoky Mountains National Park

For excellent photographs when the weather cooperates, Clingmans Dome is the highest point in Great Smoky Mountains National Park. At the observation tower on the summit, you can enjoy spectacular 360-degree views of the Smokies and beyond.

On a clear day, you can see seven states from Clingmans Dome — Tennessee, North Carolina, South Carolina, Virginia, Georgia, Kentucky and Alabama.

9. Complete Mississippi River Cruise (22 Nights)

This epic 23-day exploration of America begins in New Orleans and traverses the entire length of the Mississippi River stopping at all the most iconic ports in the region.

Complete Mississippi River Experience Itinerary

23 Nights Total: 22-night cruise plus 1 pre-cruise hotel night

Start/End Points:

• New Orleans, Louisiana
• St. Paul, Minnesota

Ports:

• New Orleans, Louisiana
• Oak Alley, Louisiana
• Baton Rouge, Louisiana
• St. Francisville, Louisiana
• Natchez, Mississippi
• Vicksburg, Mississippi
• Greenville, Mississippi
• Tunica, Mississippi
• Memphis, Tennessee
• Cape Girardeau, Missouri
• St. Louis, Missouri
• Hannibal, Missouri
• Muscatine, Iowa
• Dubuque, Iowa
• Winona, Minnesota
• Red Wing, Minnesota
• St. Paul, Minnesota

Ships that cruise this itinerary:

• American Serenade
• American Melody

Why Choose This Mississippi Cruise?

Look for the answer in the cruise details above and you’ll know. More cruise time as a reward for the hassle of flying to New Orleans to start the cruise.

Shore Excursion Tip — B.B. King Museum & Delta Interpretive Center in Indianola, Mississippi

Do this shore excursion to the B.B. King Museum in tiny Indianola (pop. 9,003) to celebrate the legendary musician's recent 100th birthday; he was born more than a century ago on Sept. 16, 1925. King chose his hometown for the museum and for where he is buried. King died in his sleep on May 14, 2015, in Las Vegas. He was 89 years old.

As a shore excursion from the Greenville port stop, the B.B. King Museum & Delta Interpretive Center is a fascinating place. Born Riley B. King in Itta Bena, Mississippi, King picked up his nickname in Memphis where he was known as the “Beale Street Blues Boy,” later shortened to B.B.

The museum is carved out of an old brick cotton mill where King once worked as a teen and the town where he played for spare change on a street corner. Seems meant to be as the most fitting site for his museum and grave.

10. Grand Heartland River Cruise (14 Nights)

Journey on the Mississippi River on this long two-week-plus cruise through the heartland of America where many of the towns still hold the charm of bygone eras. Each day is a new chapter in the story of American history and the importance of the mighty Mississippi to the founding of America.

Grand Heartland Cruise Itinerary

15 Nights Total — 14-night cruise plus 1 pre-cruise hotel night

Start/End Points:

• St. Paul, Minnesota
• New Orleans, Louisiana

Ports:

• St. Paul, Minnesota
• La Crosse, Wisconsin
• Dubuque, Iowa
• Davenport, Iowa
• Hannibal, Missouri
• St. Louis, Missouri
• Memphis, Tennessee
• Tunica, Mississippi
• Vicksburg, Mississippi
• Natchez, Mississippi
• Baton Rouge, Louisiana
• New Orleans, Louisiana

Ships that cruise this itinerary:

• American Serenade
• American Symphony
• American Heritage
• American Melody

Why Choose This Mississippi Cruise?

Variety is abundant on this cruise with so many ports and shore excursions in the Grand Heartland.

Shore Excursion Tip — Gateway Arch in St. Louis 

The tallest man-made monument in the U.S., the Gateway Arch in St. Louis is a beauty to behold.

But the spectacular 30-mile panoramic view from atop the arch is something to see — if you’re not claustrophobic or afraid of heights or have mobility issues.

The woman next to me described it as climbing into a gigantic clothes dryer and slamming the door shut. She had a point. The famous trams to the top of the arch seat up to five people for the clanking and creaking four-minute ride up and three-minute ride down.

Like a gigantic steel rainbow, the arch showcases amazing sights from the top. The 64-foot observation room has 24 windows with visitors trying to photograph everything they see. If you are worried about that tram, there is a model one that you can sit in to see how you feel before climbing into one of the real trams to ride to the top.

11. Mississippi River Gateway Cruise (10 Nights)

This exploration on the Mississippi River through America’s heartland shares interesting stops and stories about our history, music, cuisine, sports and much more, stopping at well-known sites and cities like Memphis and Vicksburg.

Mississippi River Gateway Cruise Itinerary

11 Nights Total: 10-night cruise plus 1 pre-cruise hotel night

Start/End Points:

• New Orleans, Louisiana
• Louisville, Kentucky

Ports:

• New Orleans, Louisiana
• Oak Alley/Houmas House, Louisiana
• Vicksburg, Mississippi
• Memphis, Tennessee
• Paducah, Kentucky
• Louisville, Kentucky

Ships that cruise this itinerary:

• American Symphony
• American Heritage

Why Choose This Mississippi Cruise?

Cruising into Louisville is a beautiful sight. The city’s award-winning waterfront seems to send a welcoming hug to cruise ship passengers. Louisville’s 85-acre Waterfront Park was named the No. 1 Best Riverwalk in the county by USA Today 2025 Best Readers’ Choice Awards.  

Shore Excursion Tip — Louisville Slugger Museum in Louisville, Kentucky

The museum is easy to find — just look for the world’s largest bat. Propped outside the downtown Louisville Slugger Museum is a 120-foot-tall steel bat, an exact-scale replica of Babe Ruth’s 34-inch Louisville Slugger bat.

Inside the museum, visitors can stand next to life-like statues such as Derek Jeter for photo ops. In a case of honor is the bat Babe Ruth, the greatest power hitter of all time, used during his 1927 season with 21 notches carved for each homer sit.

In the Hold a Piece of History exhibit, visitors can hoist bats used in Major League Baseball games by legends. These are genuine artifacts and real pieces of history that visitors get to hold and, of course, get photographs taken. Mickey Mantle’s bat is said to be among the most chosen.

Visitors also can take a guided tour of the plant to see how a Louisville Slugger bat is made. After the factory tour is over, visitors can leave with an appropriate souvenir — a free miniature Louisville Slugger.

12. Grand Ohio River Cruise (14 nights)

Cruising along the grand Ohio River, passengers can see the serene beauty of America’s heartland. Enjoy the gentle sweep of greenery along riverbanks and catch a glimpse of the diverse array of wildlife that thrives in this region’s rich ecosystem.

Majestic white-tail deer, smart red foxes, adorable cotton-tail rabbits and more add to the captivating tapestry of life along the Ohio River. This cruise offers an interesting view of towns many people only know from the highway side.

While the itinerary begins and ends with big cities, the Grand Ohio River Cruise focuses on small-town USA where townspeople enjoy welcoming guests to their little river world.

Grand Ohio River Cruise Itinerary

15 Nights Total: 14-night cruise plus 1 pre-cruise hotel night

Start/End Points:

• Pittsburgh, Pennsylvania
• St. Louis, Missouri

Ports:

• Pittsburgh, Pennsylvania
• Marietta, Ohio
• Maysville, Kentucky
• Cincinnati, Ohio
• Madison, Indiana
• Louisville, Kentucky
• Henderson, Kentucky/Evansville, Indiana
• Paducah, Kentucky
• St. Louis, Missouri

Ships that cruise this itinerary:

• American Symphony
• American Melody
• American Heritage

Why Choose This Mississippi Cruise?

This cruise offers a wonderful diversity of big cities and small towns. And no two of them are alike. Difficult to choose a favorite because each has its own charms.

Shore Excursion Tip — National Quilt Museum in Paducah, Kentucky

Two men standing in front of a quilt at the National Quilt Museum were debating what they were seeing. Finally, a museum guide assured the men that the sign about the quilt was accurate. The quilt is made of basswood.

Never know what you might see at the National Quilt Museum. Founded in April 1991, the museum is a mecca for quilters from around the world. With more than 13,000 square feet of exhibit space, the museum is the largest quilt and fiber art museum in the world.

The quilt exhibits change frequently throughout the year so there is something new to see on repeat visits. An additional tip is that a wonderful perk of an American Cruise Lines cruise is that we get to enjoy hop-on hop-off motor coaches in the destinations where we dock.

What I often like to do is ride the whole loop and listen to a local guide so I can get a nice look at the town or city before I decide where I want to get off first. In Paducah, the National Quilt Museum is easily walked from where our ship docked down by the city’s artistic flood walls or you can hop on that cruise bus.

13. Mississippi & Tennessee Rivers Cruise (14 Nights)

Two great rivers are combined to make this cruise a memorable pleasure. The mighty Mississippi and the scenic Tennessee River showcase music, landscapes and the rich heritage of America’s heartland.

An additional treat is days cruising the peaceful rivers when passengers can choose to sit in a comfy spot on the deck or a private balcony and watch the river flow. Or cruisers can participate in art classes, cooking demonstrations, trivia challenges, onboard guest speakers and much more as the ship glides along.

This cruise is a photographer’s dream as the rivers flow from thick forests, sandy beaches, picturesque bluffs and charming riverside towns. Sooner or later, photographers seem to find their way to the back of the ship where the hypnotic red paddlewheel is a joy to photograph and video tape for shared enjoyment.

Mississippi & Tennessee Rivers Cruise Itinerary.

15 Nights Total: 14-night cruise plus 1 pre-cruise hotel night

Start/End Points:

• New Orleans, Louisiana
• Huntsville, Alabama

Ports:

• New Orleans, Louisiana
• Oak Alley, Louisiana
• Baton Rouge, Louisiana
• St. Francisville, Louisiana
• Natchez, Louisiana
• Vicksburg, Mississippi
• Memphis, Tennessee
• Paducah, Kentucky
• Savannah, Tennessee
• Florence, Alabama
• Huntsville, Alabama

ACL ships that cruise this itinerary:

• American Heritage

Why Choose This Mississippi Cruise?

Be sure to take a camera. This cruise offers outstanding photo opportunities, even if all you want to do is share pictures with folks back home or keep the photos as wonderful memories for you. 

My Shore Excursion Pick: Oak Alley Plantation in Vacherie, Louisiana

Known as “The Grand Dame of the Great River Road,” Oak Alley Plantation got its name, of course, from its stunning one-fourth mile of 300-year-old live oaks lining the entrance to the Greek Revival antebellum home. As an added treat, we were greeted at Oak Alley with a complimentary mint julep.

A National Historic Landmark, Oak Alley has a long history, including as a sugar and rice farm, chicken farm, cattle ranch and country home. When his mother died, Jacques Thelesphore Roman came into possession of the land in 1836 and immediately began building the mansion for his wife Celina.

Roman also inherited 144 slaves. Today, the slave quarters are not original buildings but are a good example of the type of dwelling where the slaves lived. The buildings provide information about some of the slaves who lived there and what they endured.

If Oak Alley Plantation looks familiar, it has been feature in several films including being the home of Louis (Brad Pitt) in the 1994 movie “Interview with the Vampire.”

14. Mississippi & Cumberland Rivers Cruise (13 Nights)

A major waterway of the Southern United States, the 688-mile-long Cumberland River is predominantly rural but it does have some major cities including Nashville and Clarksville, both in Tennessee. The Cumberland is also a working river so look for barges hauling sand and coal along the river.

As one of the world’s great waterways, the mighty Mississippi played an important role in the development of America. Cities like New Orleans and Memphis grew into major commercial centers because of their location on the banks of the Mississippi.

This cruise features five leisurely days of cruising – on both the Mississippi and the Cumberland River. That’s one reason this cruise is so popular. Book it and find out for yourself.

Mississippi & Cumberland Rivers Cruise Itinerary.

14 Nights Total: 13-night cruise plus 1 pre-cruise hotel night

Start/End Points:

• New Orleans, Louisiana
• Nashville, Tennessee

Ports:

• New Orleans, Louisiana
• Oak Alley, Louisiana
• Baton Rouge, Louisiana
• Natchez, Mississippi
• Vicksburg, Mississippi
• Memphis, Tennessee
• Paducah, Tennessee
• Dover, Tennessee
• Clarksville, Tennessee
• Nashville, Tennessee

ACL ships that cruise this itinerary:

• American Symphony
• American Splendor

Why Choose This Mississippi Cruise?

History galore on this interesting itinerary. A tip – Natchez is the oldest town on the Mississippi River. Be sure to stop in the Under the Hill Saloon, oldest on the river and still operating.

My Shore Excursion Pick: Paducah Flood Wall in Paducah, Kentucky

I’ve visited Paducah, Kentucky, many times but always seem to learn something new on an American Cruise Lines shore excursion. The last time my grandson Logan was cruising with me and he knew immediately who the figure was on the Paducah Flood Wall.

After the Great Flood of 1937 decimated Paducah, a towering floodwall was built and covered in more than 60 beautiful murals by artist Robert Dafford. Stretching three blocks with a wide sidewalk for easy walking along the floodwall, each 14-foot-tall, 20-foot-wide mural depicts a moment in Paducah’s history.

Hidden in the wall are surprising tidbits. On this trip, tour guide Kim was explaining Paducah’s history as the “Strawberry Capital of the World” in the early 1940s. That’s when Logan spotted the image of a man sitting in the middle of the strawberry field mural.

The unmistakable fella in the artwork was wearing round wire-rimmed glasses. John Lennon. Logan was right. Kim confirmed that when she mentioned the surprising image was related to the song, “Strawberry Fields Forever.”

15. Great Smoky Mountains Land & Cruise Combo (9 Nights)

These land-and-cruise journeys from American Cruise Lines are a great gift. It’s like taking two fascinating trips without having to do any of the driving. I’m usually the driver so I have to keep my eyes on the road. And the Great Smoky Mountains have so much to see that it is wonderful to lean back, look and listen to an Adventure Guide share information about the diverse wildlife, historic homesteads and scenic overlooks for which these mountains are famous.

After enjoying the joys of the Great Smoky Mountains, on Day 5, passengers board the American Heritage cruise ship to cruise the Tennessee River. From the river, cruisers can see towering bluffs, forested banks and quiet inlets as well as the distant silhouettes of the Great Smoky and Appalachian Mountains.

As for that name, the Great Smoky Mountains are not really covered with smoke. In fact, the “smoke” is a natural bluish haze, the result of the vapor the millions of trees, bushes and other plants in the mountains give off when they exhale. The vapor often appears blue because of the blue light from the sky.

The Cherokee people originally called the area Shaconage, which translates to “land of the blue smoke.” Keep your camera handy. Many glorious photo possibilities on this trip.

Great Smoky Mountains Land & Cruise Combo Itinerary.

10 Nights Total: 9-night cruise plus 1 pre-cruise hotel night

Start/End Points:

• Knoxville, Tennessee
• Huntsville, Alabama

Ports:

• Knoxville, Tennessee
• Pigeon Forge, Tennessee
• Great Smoky Mountains National Park
• Fort Southwest Point, Tennessee
• Chattanooga, Tennessee
• Decatur, Alabama
• Huntsville, Alabama

ACL ships that cruise this itinerary:

• American Heritage

Why Choose This Mississippi Cruise?

Terrific way to see the Great Smoky Mountains, the nation’s most visited National Park. Like having a chauffeur and a knowledgeable guide taking you through the amazing park, followed by a leisurely cruise.

My Shore Excursion Pick: Dolly Parton’s Stampede in Pigeon Forge, Tennessee

Dolly Parton’s Stampede has an interesting concept for a dinner theater. While eating a four-course southern feast, patrons watch a live show in the central dirt-covered arena.

The show features thrilling horse-riding stunts, Conestoga wagons, spectacular special effects and an original song written and recorded by Dolly Parton. To celebrate Stampede’s 31st season in 2025, the new Butterfly Dreams debuted and quickly became a Stampede favorite.

Butterfly Dreams is named for Dolly’s lifelong fascination with butterflies. She considers them to be her personal symbol of freedom and beauty. In the show, Dolly’s childhood memories are bought to life through an unusual aerial and equestrian display showcasing butterfly-winged horses and specialized lighting effects.

The Dixie Belle Saloon opening act begins 50 minutes prior to the actual Dolly Parton’s Stampede. Featuring talented musicians, the show is well worth arriving early to see.

16. Arkansas River Cruise (7 Nights)

I heard the excitement as soon as this new Arkansas River Cruise was announced. Passengers were ready to book it for a journey into an important historical part of America as well as to enjoy naturally beautiful riverfronts. 

Starting with the Arkansas River, the cruise journeys down through the Lower Mississippi River with excellent shore excursions along the way. Located where the Arkansas, Verdigris and Grand Rivers converge, Muskogee is one of Oklahoma’s most historically significant cities. Legendary singer Merle Haggard famously saluted the town, saying he was “proud to be an Okie from Muskogee.”

Many of the cities and towns along this itinerary have lovely walkable riverfront parks, historic homes and artisan shops. Native American history has deep roots in this area. At the western edge of Arkansas, near the Oklahoma border, Fort Smith — established as a military outpost in 1817 — played a key role in the settlement of the American West. 

Arkansas River Cruise Itinerary.

8 Nights Total: 7-night cruise plus 1 pre-cruise hotel night

Start/End Points:

• Tulsa, Oklahoma
• Memphis, Tennessee

Ports:

• Tulsa, Oklahoma
• Muskogee, Oklahoma
• Fort Smith/Van Buren, Arkansas
• Little Rock, Arkansas
• Cleveland, Mississippi
• Memphis, Tennessee

Ships that cruise this itinerary:

• American Serenade
• American Symphony

Why Choose This Mississippi Cruise?

This brand-new cruise is setting sail for the first time in November 2026. Fall foliage has a mind of its own but this cruise should showcase some brilliant autumn colors of vibrant red, orange, yellow, purple and deep brown.

My Shore Excursion Pick: GRAMMY Museum in Cleveland, Mississippi

One of only two GRAMMY Museums in the world, the GRAMMY Museum in Cleveland, Mississippi, is filled to the brim with musical history. The Recording Academy awarded its first “Gramophone Awards” back in 1958. But the academy knew it needed a more eye-catching  name than “Gramophone,” an old-time device for playing music. In fact, the award itself is a gold-plated replica of a Gramophone.

After a mail-in contest, the name was shortened to “GRAMMY.” One of the museum’s eye-catching exhibits showcases original clothing worn on awards nights. So much glitz, glamour, flashy jewelry and out-of-this-world boots.

But the museum is more than a look-and-listen place. It also invites visitors to step on a colorful dance floor and learn new dance moves from GRAMMY winner Ne-Yo.

In the singing and songwriting/producing pods, Keb’ Mo’ (an American blues musician) welcomes visitors to write and record their own blues song and then produce the collaboration inside the production pod. In the museum's “Roland Room,” visitors are invited to play electronic musical instruments.

17. Mississippi & Ohio Rivers Cruise (12 Nights)

This voyage through the heart of America traces the historic waterways of the Lower Mississippi and Ohio Rivers. Starting with an overnight in New Orleans, landmark shore excursions are offered at post stops including the iconic Oak Alley estate; the story of Gov. and Senator Huey P. Long at the magnificent 1852 Old State Capitol Museum in Baton Rouge; and the unfinished mansion Longwood in Natchez where construction work was stopped when the Civil War began.

Take the Vicksburg National Military Park shore excursion to learn how the Vicksburg battle site was a pivotal turning point in the Civil War. Tour the National Civil Rights Museum in Memphis and see the Lorraine Motel room where Martin Luther King spent his last night and was assassinated by James Earl Ray when MLK stepped on the motel balcony on April 4, 1968.

Mississippi & Ohio Rivers Cruise Itinerary.

13 Nights Total: 12-night cruise plus 1 pre-cruise hotel night

Start/End Points:

• New Orleans, Louisiana
• Louisville, Kentucky

Ports:

• New Orleans, Louisiana
• Oak Alley, Louisiana
• Baton Rouge, Louisiana
• Natchez, Mississippi
• Memphis, Tennessee
• Paducah, Kentucky
• Louisville, Kentucky

ACL Ships that cruise this itinerary:

• American Symphony

Why Choose This Mississippi Cruise?

History comes alive on this cruise with so many interesting shore excursions. A great cruise to celebrate America’s 250th birthday. Or to celebrate any time.

My Shore Excursion Pick:  Stax Museum of American Soul Music in Memphis, Tennessee

Jim Stewart was a part-time fiddle player and bank teller who wanted to make music. His sister, Estelle Axton, was a schoolteacher who wanted to run a record store.

Together they formed Stax Records — the “St” for Stewart, the “ax” for Axton. And the sounds from their modest recording studio set the music world on its ear. Their unique blend of soul revolutionized music and made their Memphis facility a mecca for musicians of all colors, ages and walks of life.

From 1960 to 1975, Stax placed more than 167 hit songs in the top 100 on the pop charts and an astounding 243 hits in the top 10 rhythm and blues charts. With a catalog of 800 single and 300 full album recordings, Stax was home for American cultural icons like Otis Redding, Isaac Hayes, Sam & Dave, Carla Thomas, The Staple Singers, Booker T. & the MGs, Rufus Thomas, Johnnie Taylor, The Emotions, The Memphis Horns and more.

Then came two major death blows. In 1967, Otis Redding's plane crashed into Lake Monona, Wisconsin, killing the singer and most of the Bar-Kays who were touring with him. Released posthumously, “Sittin' on the Dock of the Bay” became a No. 1 hit and a big part of Otis Redding's legacy.

In 1968, Memphis suffered its most wrenching moment — the assassination of Martin Luther King Jr. on April 4, 1968. MLK was shot down at the Lorraine Motel just a few blocks south of Stax Records. Riots ensued. The bottom fell out of Stax. By 1976, Stax had gone bankrupt.

To hear the amazing comeback story, take the Stax Museum shore excursion when the ship docks in Memphis.

Hope You Enjoyed This Rundown of American's 17 River Cruises on the Mississippi and Its Tributaries

 

 

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